Fiddlesticks Runes explained
There's one set of runes for Fiddlesticks on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Fiddlesticks rune paths on the position 
Jungle are 
Inspiration as the primary path and 
Domination as the secondary path with a pick rate of 78%. Besides picking runes on Fiddlesticks you should learn how to play Fiddlesticks and if you are interested in pro matches take a look on how a pro builds Fiddlesticks. If you want to discuss 
Fiddlesticks then you should visit the champion subreddit.
Fiddlesticks runes from primary path
Inspiration opens creative opportunities on Fiddlesticks troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Fiddlesticks. Other primary runes on Fiddlesticks are 
Triple Tonic, 
Future's Market and 
Cosmic Insight.
You will receive a 
Perfectly Timed Stopwatch for free, which can cause a moment of surprise for your enemy team. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Cosmic Insight grants summoner spell and item haste.
Fiddlesticks runes from secondary path
When it comes to your secondary path, most Fiddlesticks players prefer to go with Domination. Domination improves burst damage and assassination tools on Fiddlesticks. On the Domination path, the best runes for Fiddlesticks are 
Ultimate Hunter and 
Cheap Shot.
Ultimate Hunter scales up Fiddlesticks ultimate haste on every unique champion takedown. Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Fiddlesticks.
FAQ for Fiddlesticks Runes
Which is the best keystone rune on Fiddlesticks?
The best keystone rune on Fiddlesticks is First Strike. This Fiddlesticks runes setup is then referred as Fiddlesticks First Strike.
What runes does Fiddlesticks use?
Runes from the paths Inspiration and Domination are the most used runes on Fiddlesticks. For the exact pick rates of Fiddlesticks runes used, you have to study the rune distribution presented.