Ekko Runes explained
There's one set of runes for Ekko on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Ekko rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 53%. Besides picking runes on Ekko you should learn how to play Ekko and if you are interested in pro matches take a look on how a pro builds Ekko. If you want to discuss 
Ekko then you should visit the champion subreddit.
Ekko runes from primary path
Domination improves burst damage and assassination tools on Ekko. Most of high elo players – and our LoL pros in the the major regions – have agreed that First Strike is the best keystone rune to run on Ekko. Other primary runes on Ekko are 
Sudden Impact, 
Eyeball Collection and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Ekko with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Ekko additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Ekko will gain an additional 70 gold for the first takedown. Ekko acquires Bounty Hunter Stacks, which Ekko may use to get more takedowns. This rune's power will grow tremendously, and Ekko will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Ekko will get an additional twenty gold.
Ekko runes from secondary path
When it comes to your secondary path, most Ekko players prefer to go with Inspiration. Inspiration opens creative opportunities on Ekko troughout the match. On the Inspiration path, the best runes for Ekko are Magical Footwear and Cosmic Insight.
Magical Footwear allows Ekko to focus on those essential core items without the need to spend the additional 300 gold on boots. Cosmic Insight grants summoner spell and item haste.
FAQ for Ekko Runes
Which is the best keystone rune on Ekko?
The best keystone rune on Ekko is First Strike. This Ekko runes setup is then referred as Ekko First Strike.
What runes does Ekko use?
Runes from the paths Domination and Inspiration are the most used runes on Ekko. For the exact pick rates of Ekko runes used, you have to study the rune distribution presented.