Kha'Zix Runes explained
There's one set of runes for Kha'Zix on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Kha'Zix rune paths on the position 
Jungle are 
Inspiration as the primary path and 
Domination as the secondary path with a pick rate of 89%. Besides picking runes on Kha'Zix you should learn how to play Kha'Zix and if you are interested in pro matches take a look on how a pro builds Kha'Zix. If you want to discuss 
Kha'Zix then you should visit the champion subreddit.
Kha'Zix runes from primary path
Inspiration opens creative opportunities on Kha'Zix troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Kha'Zix. Other primary runes on Kha'Zix are 
Magical Footwear, 
Future's Market and 
Cosmic Insight.
Magical Footwear allows Kha'Zix to focus on those essential core items without the need to spend the additional 300 gold on boots. You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Cosmic Insight grants summoner spell and item haste.
Kha'Zix runes from secondary path
When it comes to your secondary path, most Kha'Zix players prefer to go with Domination. Domination improves burst damage and assassination tools on Kha'Zix. On the Domination path, the best runes for Khazix are 
Treasure Hunter and 
Sudden Impact.
Treasure Hunter is the final rune of the Domination path. This rune gives Kha'Zix additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Kha'Zix will gain an additional 70 gold for the first takedown. Kha'Zix acquires Bounty Hunter Stacks, which Kha'Zix may use to get more takedowns. This rune's power will grow tremendously, and Kha'Zix will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Kha'Zix will get an additional twenty gold. Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Kha'Zix with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier.
FAQ for Kha'Zix Runes
Which is the best keystone rune on Kha'Zix?
The best keystone rune on Kha'Zix is First Strike. This Kha'Zix runes setup is then referred as Kha'Zix First Strike.
What runes does Kha'Zix use?
Runes from the paths Inspiration and Domination are the most used runes on Kha'Zix. For the exact pick rates of Kha'Zix runes used, you have to study the rune distribution presented.