Gangplank Runes explained
There's one set of runes for Gangplank on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Gangplank rune paths on the position 
Top are 
Inspiration as the primary path and Resolve as the secondary path with a pick rate of 49%. Besides picking runes on Gangplank you should learn how to play Gangplank and if you are interested in pro matches take a look on how a pro builds Gangplank. If you want to discuss 
Gangplank then you should visit the champion subreddit.
Gangplank runes from primary path
Inspiration opens creative opportunities on Gangplank troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that First Strike is the best keystone rune to run on Gangplank. Other primary runes on Gangplank are Magical Footwear, Biscuit Delivery and Cosmic Insight.
Magical Footwear allows Gangplank to focus on those essential core items without the need to spend the additional 300 gold on boots. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Gangplank runes from secondary path
When it comes to your secondary path, most Gangplank players prefer to go with Resolve. Resolve empowers the survivability of Gangplank and increases the tankiness. On the Resolve path, the best runes for Gangplank are Overgrowth and Bone Plating.
Overgrowth increases your maximum amount of health. Bone Plating make Gangplank overall tankier, by decreasing the amount of poke damage in the early game.
FAQ for Gangplank Runes
Which is the best keystone rune on Gangplank?
The best keystone rune on Gangplank is First Strike. This Gangplank runes setup is then referred as Gangplank First Strike.
What runes does Gangplank use?
Runes from the paths Inspiration and Resolve are the most used runes on Gangplank. For the exact pick rates of Gangplank runes used, you have to study the rune distribution presented.