Ashe Runes explained
There's one set of runes for Ashe on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Ashe rune paths on the position 
Support are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 97%. Besides picking runes on Ashe you should learn how to play Ashe and if you are interested in pro matches take a look on how a pro builds Ashe. If you want to discuss 
Ashe then you should visit the champion subreddit.
Ashe runes from primary path
Domination improves burst damage and assassination tools on Ashe. Most of high elo players – and our LoL pros in the the major regions – have agreed that Hail of Blades is the best keystone rune to run on Ashe. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. Other primary runes on Ashe are Cheap Shot, Zombie Ward and Ultimate Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Ashe. Zombie Ward helps you to expand your vision on the map. Vision is very
crucial in LoL and helps you to avoid unnecessary deaths. Ultimate Hunter scales up Ashe ultimate haste on every unique champion takedown.
Ashe runes from secondary path
When it comes to your secondary path, most Ashe players prefer to go with Inspiration. Inspiration opens creative opportunities on Ashe troughout the match. On the Inspiration path, the best runes for Ashe are 
Biscuit Delivery and 
Approach Velocity.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Ashe gains bonus movement speed by Approach Velocity, while moving toward enemy champions that are immobilized or slowed. This rune is perfect to follow up engages by your teammates.
FAQ for Ashe Runes
Which is the best keystone rune on Ashe?
The best keystone rune on Ashe is Hail of Blades. This Ashe runes setup is then referred as Ashe Hail of Blades.
What runes does Ashe use?
Runes from the paths Domination and Inspiration are the most used runes on Ashe. For the exact pick rates of Ashe runes used, you have to study the rune distribution presented.