Vayne Runes explained
There's one set of runes for Vayne on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Vayne rune paths on the position 
Adc are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 66%. Besides picking runes on Vayne you should learn how to play Vayne and if you are interested in pro matches take a look on how a pro builds Vayne. If you want to discuss 
Vayne then you should visit the champion subreddit.
Vayne runes from primary path
Precision improves attack and sustained damage on Vayne troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Vayne. This keystone rune gives Vayne a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Vayne are 
Triumph, 
Legend: Alacrity and 
Coup de Grace.
Triumph restores on Vayne a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Vayne. Vayne deals with Coup de Grace more damage to targets with low health.
Vayne runes from secondary path
When it comes to your secondary path, most Vayne players prefer to go with Resolve. Resolve empowers the survivability of Vayne and increases the tankiness. On the Resolve path, the best runes for Vayne are Overgrowth and Conditioning.
Overgrowth increases your maximum amount of health. Conditioning powers up Vayne tankiness after the laning phase.
FAQ for Vayne Runes
Which is the best keystone rune on Vayne?
The best keystone rune on Vayne is Lethal Tempo. This Vayne runes setup is then referred as Vayne Lethal Tempo.
What runes does Vayne use?
Runes from the paths Precision and Resolve are the most used runes on Vayne. For the exact pick rates of Vayne runes used, you have to study the rune distribution presented.