Syndra Runes explained
There's one set of runes for Syndra on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Syndra rune paths on the position 
Mid are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 46%. Besides picking runes on Syndra you should learn how to play Syndra and if you are interested in pro matches take a look on how a pro builds Syndra. If you want to discuss 
Syndra then you should visit the champion subreddit.
Syndra runes from primary path
Sorcery empoweres abilities of Syndra and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Syndra. Other primary runes on Syndra are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Syndra runes from secondary path
When it comes to your secondary path, most Syndra players prefer to go with Inspiration. Inspiration opens creative opportunities on Syndra troughout the match. On the Inspiration path, the best runes for Syndra are 
Cosmic Insight and 
Biscuit Delivery.
Cosmic Insight grants summoner spell and item haste. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Syndra Runes
Which is the best keystone rune on Syndra?
The best keystone rune on Syndra is First Strike. This Syndra runes setup is then referred as Syndra First Strike.
What runes does Syndra use?
Runes from the paths Sorcery and Inspiration are the most used runes on Syndra. For the exact pick rates of Syndra runes used, you have to study the rune distribution presented.