Ekko Runes explained
There's one set of runes for Ekko on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Ekko rune paths on the position 
Mid are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 70%. Besides picking runes on Ekko you should learn how to play Ekko and if you are interested in pro matches take a look on how a pro builds Ekko. If you want to discuss 
Ekko then you should visit the champion subreddit.
Ekko runes from primary path
Domination improves burst damage and assassination tools on Ekko. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Ekko. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Ekko are 
Sudden Impact, 
Eyeball Collection and 
Ultimate Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Ekko with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Ultimate Hunter scales up Ekko ultimate haste on every unique champion takedown.
Ekko runes from secondary path
When it comes to your secondary path, most Ekko players prefer to go with Sorcery. Sorcery empoweres abilities of Ekko and increases the available champion resources. On the Sorcery path, the best runes for Ekko are Absolute Focus and Scorch.
Absolute Focus grants additional damage while Ekko is alomst full health. Scorch increases your control in the early game.
FAQ for Ekko Runes
Which is the best keystone rune on Ekko?
The best keystone rune on Ekko is Electrocute. This Ekko runes setup is then referred as Ekko Electrocute.
What runes does Ekko use?
Runes from the paths Domination and Sorcery are the most used runes on Ekko. For the exact pick rates of Ekko runes used, you have to study the rune distribution presented.